abstract：:The term activation is used to designate biochemical and functional changes that are induced in macrophages by a variety of stimuli, including interaction with microbial products, synthetic substances, immunoglobulins of different classes, and factors released by lymphocytes. The changes observed comprise an increased...

journal_title：Advances in experimental medicine and biology

authors： Mauel J

更新日期：1982-01-01 00:00:00

abstract：:During the past decade the mechanism of CTL-mediated killing has been resolved into 3 steps, and its cation requirements, and general nature have been well defined. However, biochemical understanding of the CTL-target interaction has made little progress. Recently, we have developed a monoclonal antibody (MAb) which b...

journal_title：Advances in experimental medicine and biology

authors： Martz E,Davignon D,Kürzinger K,Springer TA

更新日期：1982-01-01 00:00:00

abstract：:Oocyte maturation is controlled by a combination of hormonal and local follicular factors. Osmolarity, pH, and perhaps Ca2+ concentration of the surrounding medium are also important. Follicular fluid contains a low molecular weight OMI which acts to keep the oocyte from maturing. Luteinizing hormone added to cultured...

journal_title：Advances in experimental medicine and biology

authors： Channing CP,Pomerantz SH,Bae IH,Evans VW,Atlas SJ

更新日期：1982-01-01 00:00:00

abstract：:Metastasizing and non-metastasizing transplantable mammary tumors were implanted into female W/Fu rats. A pair of tumors were employed, the SMT-2A and MT-W9B. When these tumors were exposed to water bath heating at 43.5 degrees C for 60 minutes, a significantly longer tumor-free growth delay was obtained in the metast...

journal_title：Advances in experimental medicine and biology

authors： Yatvin MB,Vorpahl J,Kim U

更新日期：1982-01-01 00:00:00

abstract：:Terminal Transferase (TdT), Adenosine Deaminase (ADA), immunological membrane markers, cytochemical reactivity and cytogenetics were analyzed in 226 patients with ALL, AUL and AML, in 70 patients with CML and in 3 cases of Ph' positive acute leukemia presenting as ALL. TdT was tested in peripheral blood and bone marro...

journal_title：Advances in experimental medicine and biology

authors： Brusamolino E,Bertazzoni U,Isernia P,Ginelli E,Scovassi AI,Zurlo MG,Plevani P,Sacchi N,Bernasconi C

更新日期：1982-01-01 00:00:00

abstract：:Through the efforts of Correa, Cuello, Haenszel, Tannenbaum and others it was learned that the incidence of gastric cancer in certain areas of Narino (Colombia) was among the highest in the world. These areas of high risk for gastric cancer were adjacent to an area of substantially lower risk. Gastric biopsies from he...

journal_title：Advances in experimental medicine and biology

authors： Broitman SA,Velez H,Vitale JJ

更新日期：1981-01-01 00:00:00

abstract：:Possible non-transmitter roles for 5-HT in different phases of early neuroembryogenesis have been discussed based upon experimental evidence from the rat and chick. Fluorescence histochemical studies have demonstrated sites of uptake and synthesis of 5-HT in the chick embryo during the first few days of incubation. Th...

journal_title：Advances in experimental medicine and biology

authors： Lauder JM,Wallace JA,Krebs H

更新日期：1981-01-01 00:00:00

abstract：:All results presented here would indicate that serotonin plays an important role in animal behavior such as locomotor depression and that, taking into consideration the effects of antidepressants on 5-HT receptor activity as well as recent biochemical findings of human depression, some forms of human depression could ...

journal_title：Advances in experimental medicine and biology

authors： Takahashi R,Tateishi T,Yoshida H,Nagayama H,Tachiki KH

更新日期：1981-01-01 00:00:00

abstract：:DES is metabolized to a number of compounds through a minimum of three main metabolic routes. These routes result in some inactivity of DES as an estrogen, but the majority appear to produce estrogenic by-products, which in some cases produce divergent in vivo and in vitro hormone activities. Therefore, if DES undergo...

journal_title：Advances in experimental medicine and biology

authors： Korach KS

更新日期：1981-01-01 00:00:00

abstract：:Progress in studies on the scrapie agent has been hampered by the slow and tedious endpoint titration assays in rodents. A new assay based on incubation period measurements has been developed. The incubation period is defined as the time interval from inoculation to the onset of clinically detectable neurological illn...

journal_title：Advances in experimental medicine and biology

authors： Prusiner SB,Cochran SP,Downey DE,Groth DF

更新日期：1981-01-01 00:00:00

abstract：:Adult male Wistar rats were fed nutritionally adequate liquid diets providing 35% of the total calories as ethanol, while pair-fed controls received the corresponding diet with ethanol replaced by an equicaloric concentration of sucrose. After 2, 4, 6, 8, 10 and 14 weeks of chronic ethanol treatment, separate groups o...

journal_title：Advances in experimental medicine and biology

authors： Khanna JM,Kalant H,Lê AD,LeBlanc AE

更新日期：1980-01-01 00:00:00

abstract：:The effects of ethanol on DNA and protein synthesis of regenerating rat liver has been studied. A single dose of ethanol, when given either before, at the time or 1 h after the partial hepatectomy significantly inhibited the accelerated synthesis of ornithine decarboxylase protein which was used as a marker of protein...

journal_title：Advances in experimental medicine and biology

authors： Pösö R,Pösö H,Väänänen H,Salaspuro M

更新日期：1980-01-01 00:00:00

abstract：:The relationships between bilayer lipid, diffusional and conformational activities of oxidoreduction components, and electron transfer activity in the mitochondrial inner membrane are considered. Using a new, low pH method to fuse liposome phospholipid (asolectin) with the isolated mitochondrial inner membrane, the me...

journal_title：Advances in experimental medicine and biology

authors： Hackenbrock CR,Schneider H,Lemasters JJ,Höchli M

更新日期：1980-01-01 00:00:00

abstract：:Lipid composition and Ca2+ transport properties were examined in the isolated sarcoplasmic reticulum of non-exercised muscles of markedly phosphorus depleted rats. Phosphorous depletion with a fall of plasma Pi from 8.04 +/- 0.85 to 2.56 +/- 0.48 mg/dl was accompanied by a decrease in muscle Pi and ATP content and by ...

journal_title：Advances in experimental medicine and biology

authors： Kreusser W,Ritz E,Boland R,Brachmann J

更新日期：1980-01-01 00:00:00

abstract：:The clinical aspects of gout were described based on the 4,112 patients observed in the same clinic. In this paper mainly, 2,455 cases seen between 1958 and 1973 were described based on a pretrospective computer assisted analysis. The age distribution of the patient had its peak at 50 years of age and the average age ...

journal_title：Advances in experimental medicine and biology

authors： Nishioka N,Mikanagi K

更新日期：1980-01-01 00:00:00

abstract：:1. The age and sex distribution of the SUA of the Japanes people was the same as of the Caucasians. 2. The prevalence of gout was 0.4% of all the subjects, in adult male it was 1.2% and 76.4% in hyperuricemia above 10.0 mg/dl. 3. The incidence of a year throughout this population study was 0.02% per population. 4. Ser...

journal_title：Advances in experimental medicine and biology

authors： Nishioka K,Mikanagi K

更新日期：1980-01-01 00:00:00

abstract：:Many similarities were observed in the behavioral and neurochemical actions of ethanol and chlordiazepoxide (CDZ) suggesting that these agents may share common mechanisms of action. However, similarities in these actions could not be explained by effects on a benzodiazepine binding site, since only CDZ interacted with...

journal_title：Advances in experimental medicine and biology

authors： Frye GD,Vogel RA,Mailman RB,Ondrusek MG,Wilson JH,Mueller PA,Breese GR

更新日期：1980-01-01 00:00:00

abstract：:Hyp mice have a defective control system for the synthesis of 1,25-(OH)2-vitamin D that does not respond to a low phosphate stimulus. While the plasma levels of 25-OH-vitamin D are reduced somewhat, this seems to be not a serious defect since plasma 1,25-(OH)2-vitamin D levels are normal. Hyp kidneys synthesize and ex...

journal_title：Advances in experimental medicine and biology

authors： Meyer RA Jr,Gray RW,Kiebzak GM,Mish PM

更新日期：1980-01-01 00:00:00

abstract：:Acute ethanol loading in the rat induces hypocalcemia and hypermagnesemia. In addition, hypocalcemia is not corrected by exogenous PTH. In the rat the mechanism of these changes was investigated by measuring plasma immunoreactive parathyroid hormone (PTH). PTH was also measured in culture medium in which parathyroid g...

journal_title：Advances in experimental medicine and biology

authors： Chanard J,Lacour B,Drüeke T,Brunois JP,Ruiz JC

更新日期：1980-01-01 00:00:00

abstract：:Horse liver alcohol dehydrogenase was carboxymethylated at the active site Cys-46 using 90% [1-13C]bromoacetate. The enriched carboxylate resonance was studied in the absence and presence of coenzymes and inhibitors. Previous ambiguities regarding the resonance in the NAD+ complex have now been resolved. However, it i...

journal_title：Advances in experimental medicine and biology

authors： Jones DT,Khalifah RG

更新日期：1980-01-01 00:00:00

abstract：:Liver alcohol dehydrogenase is shown to catalyze dehydrogenation, dismutation and esterolysis. These multifunctional activities were found to associate with all isozymes. The reversible dehydrogenation of alcohols takes place via a random mechanism with a pathway for the formation of enzyme-NADH-alcohol complex which ...

journal_title：Advances in experimental medicine and biology

authors： Tsai CS

更新日期：1980-01-01 00:00:00

abstract：:The uric-acid lowering effect was investigated in a group of 2220 patients. 1984 of these were employed for statistical evaluation purposes. On average, the uric acid level was reduced from 8,24 +/- 1,16 mg/100 ml to 5,32 +/- 1,265 mg/100 ml. In 82 % of all the cases, the uric acid level at the end of the treatment pe...

journal_title：Advances in experimental medicine and biology

authors： Ferber H,Bader U,Matzkies F

更新日期：1980-01-01 00:00:00

abstract：:Aqueous dispersions of pure gangliosides contain micelles of these compounds. In this dispersion state, the rates of hydrolysis of the neuraminyl residues by bacterial neuraminidases are slowest. Incorporation of gangliosides into mixed dispersion with other lipids or into mixed micelles with bile salts considerably i...

journal_title：Advances in experimental medicine and biology

authors： Gatt S,Gazit B,Cestaro B,Barenholz Y

更新日期：1980-01-01 00:00:00

abstract：:Significantly lower concentrations of norepinephrine were observed in whole brain and hypothalamus of pups exposed to ethanol pre- and post-natally as compared to controls. Dopamine levels were found to be unaltered in whole brain compared to controls although hypothalamus and corpus striatum demonstrated a decreased ...

journal_title：Advances in experimental medicine and biology

authors： Detering N,Collins R,Hawkins RL,Ozand PT,Karahasan AM

更新日期：1980-01-01 00:00:00

abstract：:Three novel trisialogangliosides of fish brain, GT3, GT2 and GT1c, have been isolated in their intact forms and their structures characterized. The discovery of these ganglioside species provides essential links for a new possible biosynthetic pathway leading to the major tetrasialoganglioside, GQ1c, of the fish brain...

journal_title：Advances in experimental medicine and biology

authors： Yu RK,Ando S

更新日期：1980-01-01 00:00:00

abstract：:Studies have been cazrried out to determine the in vivo and in vitro effects of lithium carbonate in various neutropenic disorders. Addition of lithium to culture of bone marrow from patients with a variety of neutropenic disorders and ANLL in which normal or elevated serum and/or urinary CSA levels were present did n...

journal_title：Advances in experimental medicine and biology

authors： Robinson WA,Entringer MA,Huber J,Gupta R

更新日期：1980-01-01 00:00:00

abstract：:We studied hepatic mitochondria to determine the effects of ethanol in vitro and of chronic ethanol consumption on the temperature dependence (10 degrees-45 degrees C) of a) substrate oxidation, and b) ATP hydrolysis, with or without CCCP. Arrhenius plots showed the characteristic breaks around 20 degrees C both for e...

journal_title：Advances in experimental medicine and biology

authors： Rottenberg H,Robertson DE,Rubin E

更新日期：1980-01-01 00:00:00

abstract：:Compared to controls receiving physiological saline, the i.p. administration of dimethylnitrosamine (DMN) on 5 consecutive days to rats fed a nutritionally adequate liquid diet resulted 24 hours after the last injection of significant increases in glutamic dehydrogenase (GDH), glutamic oxylacetate transaminase (GOT), ...

journal_title：Advances in experimental medicine and biology

authors： Gellert J,Moreno F,Haydn M,Oldiges H,Frenzel H,Teschke R,Strohmeyer G

更新日期：1980-01-01 00:00:00

abstract：:In vitro NWSM has been shown to be a B cell mitogen and a polyclonal activator. Although NWSM has been also shown to be adjuvant active in vivo, motogenicity and polyclonal activation are not observed when this fraction has been administered to mice. In contrast, the experiments reported here demonstrate that after in...

journal_title：Advances in experimental medicine and biology

authors： Löwy I,Juy D,Bono C,Chedid L

更新日期：1979-01-01 00:00:00

abstract：:Kallikrein was purified from horse kidney by several steps of chromatographic procedure and by affinity chromatography on Sepharose-Concanavaline. Horse urinary kallikrein was previously purified by DE-32 hydroxylapatite and by Sephadex G-100 gel filtration. On the purified final sample of renal and urinary kallikrein...

journal_title：Advances in experimental medicine and biology

authors： Porcelli G,Marini-Bettolo GB,Croxatto HR,Di Jorio M

更新日期：1979-01-01 00:00:00

abstract：:We have briefly discussed immunogenetic studies of families with hyperglycemia which suggest the existence of at least four types of the disease: a) juvenile, insulin-dependent, ketosis prone diabetes determined by an autosomal recessive gene with 50% penetrance and in linkage with the HLA; b) juvenile, insulin-depend...

journal_title：Advances in experimental medicine and biology

authors： Barbosa J,Chern MM

更新日期：1979-01-01 00:00:00

abstract：:Duration and quality of life are considerably reduced in insulin-dependent diabetic patients, but regular metabolic supervision, education of the patients, and social support can reduce the prevalence of severe late diabetic complications and prolong life by about 10 years. ...

journal_title：Advances in experimental medicine and biology

authors： Deckert T,Larsen M

更新日期：1979-01-01 00:00:00

abstract：:Plasma renin activity, blood angiotensin I, urinary kallikrein and blood bradykinin levels have been measured concurrently in rats over a range of daily sodium intake. Plasma renin activity, blood angiotensin I levels and urinary kallikrein were significantly increased by the low sodium diet (0.02 mmole per day). Brad...

journal_title：Advances in experimental medicine and biology

authors： Matthews PG,Johnston CI

更新日期：1979-01-01 00:00:00

abstract：:Anhydrotrypsin, a derivative of bovine trypsin, immobilized on Sepharose tightly adsorbs various peptides containing L-arginine at the carboxyl termini, such as bradykinin and tuftsin. These peptides correspond to the specific products of the action of trypsin-like enzymes. Native trypsin immobilized on Sepharose does...

journal_title：Advances in experimental medicine and biology

authors： Ishii S,Yokosawa H,Shiba S,Kasai K

更新日期：1979-01-01 00:00:00

abstract：:Uterine peroxidase enzyme activity has been studied as a marker for estrogen action in the uterus to help clarify the mechanism of estrogen action and its modulation by antiestrogens and progestins. Estrogen-induced increases in peroxidase were found to closely parallel increases in uterine weight and DNA content in t...

journal_title：Advances in experimental medicine and biology

authors： DeSombre ER,Lyttle CR

更新日期：1979-01-01 00:00:00

abstract：:Intraperitoneal treatment with the enzyme inhibitor, pepstatin, of BSVS mice, guinea pigs and Lewis rats which were sensitized with guinea pig spinal cord and pertussis vaccine resulted in complete or partial suppression of paralysis dependent on the species studied and alterations of histological signs of experimenta...

journal_title：Advances in experimental medicine and biology

authors： Boehme DH,Marks N

更新日期：1979-01-01 00:00:00

abstract：:Methylated endotoxin and Freeman-type polysaccharide each stimulate granulopoiesis and the production of CSF in mice. These same preparations also protect pretreated mice from lethal X-irradiation. The role of CSF in stimulating granulopoiesis in vivo was shown by the ability of anti-CSF to reduce the number of CFUc i...

journal_title：Advances in experimental medicine and biology

authors： Urbaschek R

更新日期：1979-01-01 00:00:00

abstract：:De novo synthesis of RNA sequences corresponding to intervening as well as to structural sequences of the ovalbumin gene have been detected in isolated oviduct nuclei. Their presence in the nuclear transcripts and their time course of induction support the hypothesis that transcription of structural and intervening se...

journal_title：Advances in experimental medicine and biology

authors： Swaneck GE,Tsai SY,Tsai MJ,Nordstrom JL,Roop DR,O'Malley BW

更新日期：1979-01-01 00:00:00

abstract：:Studies in this laboratory on the nuclear binding sites (acceptors) for progesterone receptor in the developed chick oviduct have resulted in the detection of seasonal variations in the levels and functions of the receptor. Cytosol preparations obtained from the chick oviducts during the winter/spring period between J...

journal_title：Advances in experimental medicine and biology

authors： Spelsberg TC,Boyd PA,Halberg F

更新日期：1979-01-01 00:00:00

abstract：:The leukokinin-leukokininogen system is a pathological kinin generating system which is catalyzed by acid proteases present in neoplastic cells, white cells and even normal tissues. The components of the human system including leukokinin-H and leukokininogen have now been isolated and characterized. Very specific prot...

journal_title：Advances in experimental medicine and biology

authors： Greenbaum LM,Semente G,Grebow P,Roffman S

更新日期：1979-01-01 00:00:00